I travel whatever road makes the most sense for the trip. Yesterday I drove the car down to Paducah, KY for a rod run, came back last night as the weather looked bad last night and all day today. I took interstate all the way down as it was an hour and a half trip vs over two hours on a two lane road. I enjoy driving the 2 lane or 4 lane highways, with about a 60 mph speed limit.
With dual carbs, OD, 3.55 rear, it drives pretty comfortable at 65-70mph. Gets real good gas mileage too without the stop and go traffic. I like to leave earlier in the day if I'm traveling and avoid the freeways in the evening when they are the most crowded.