Yes anything with 3.9, 4.10, 4.3, gonna be busy at 50-60 mph.
My engine is not busy at 60 mph yet, but the old truck is a bit......LOL
Yes insulation, tires, suspension condition, driveline balance, will all contribute to the ride quality at higher speeds.
I wonder in my case, with 3.23 gears, how an OD trans, say a T5 for example might be. I would think I would be in 4th most of the time under about 55 mph, and needing to downshift against high winds or hills from 5th to 4th.
I do find my gear spread, from 3rd to 4th not that pleasant with 3.23 gears. I still have to take off in 2nd, 1st is way too low even with a 3.23 rear end. Pickup from 2nd to 3rd is nice, 3rd to 4th is okay, once in 4th she is not overly speedy until about 50 mph....