Because of my back, I have certain limitations that I need to recognize, not only in lifting heavy objects but in working positions. As nice as the QuadCab rides, I start having issues after 45 minutes that I need to make adjustments...a few years ago I made a couple of trips to West TX that were about 600 miles apiece that about wiped me out. The Laramie rides way better, so much so that I have made several weekend trips up into CO, 1700 miles round trip, sometimes twice a month, without any problems. One return trip turned into an odyssey that detoured into KS, stretching that into a 15hr marathon that left me mentally fatigued but without lingering effects the next days.
The big difference between them two trucks is the seats, as the QuadCab has effectively a split bench, but the Laramie has vented bucket seats with adjustable lumbar and seat angle...firm but comfortable. I recall several squarebox chevies and my old D250 having bench seats not much better than the B-series buggies that were over 25yrs older. The QuadCab seats were finally a big improvement in truck seating when they debuted, and the ensuing generations have gotten even better, making these long road trips tolerable for us hobbled goobers.